There are many important constituents to cranberry fruit that aren’t often captured in either cranberry extracts or juice powders. If you’re doing a clinical study on any raw ingredient or formulated product, you should be mandated to know its composition. How else can you link the efficacy with the material used?

What good are studies if they cannot be measured or replicated? Companies involved with promoting fruit polyphenols are following Fruit d’Or’s lead by recognizing the importance of using the newest and best reference standard: cranberry proanthocyanidin (C-PAC). The process should be to first identify your cranberry, know what’s in it (such as its PAC activity), link the PAC to standardization, then conduct the study to establish efficacy.

“It is critically important to choose the most appropriate reference standard,” confirms Complete Phytochemical Solutions CEO Christian Krueger, who has introduced breakthrough test methods for measuring cranberry’s soluble and insoluble PACs and has also developed new reference standards such as C-PAC.

Krueger et al have developed and recommend the adoption of a C-PAC reference standard to improve the accuracy of cranberry PAC quantification. “The C-PAC standard reflects the structural heterogeneity of cranberry PAC: degree of polymerization, hydroxylation pattern and ratios of ‘A-type’ to ‘B-type’ interflavanyl bonds. The adoption of C-PAC standard should be considered as an improvement over the use of the procyanidin A2 dimer reference standard,” explains Krueger. “The use of C-PAC reference standard improves quantification of both soluble and insoluble cranberry PAC. Improved standardization of bioactive PAC components in functional cranberry foods will aid in establishment of dosage guidelines.” The Cranberry Institute is the latest organization that has recognized the importance of the C-PAC and has adopted this reference standard in the testing of whole fruit cranberry.

Fruit D’Or is the first and only cranberry company to recognize the importance of the C-PAC reference standard for its whole fruit powders. Without identifying the starting cranberry powder with the right analytical tools, test methods and reference standards it’s difficult to obtain credible and reliable research. These are all critical factors for taking Cranberry beyond UTIs and educating consumers on quality differences.
Up to now, most nutraceutical companies have been using the wrong reference standards to measure PACs in both cranberry juice extract powders and whole-fruit cranberry powders. This has resulted in inaccurate test results and misleading label claims by companies. Combined with the use of the right test methods, the C-PAC reference standard can help the nutraceutical companies  create standardization, confirm efficacy and give the  consumers cranberry  products that deliver on promise. This is all necessary in order to debunk the junk of inferior cranberry products and protect the health and safety of consumers  



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