Because consumers buy cranberry products for their health benefits, it is essential for suppliers to formulate those products so that they deliver on promises. The only way to accomplish that is to know and use the state-of-the-art science behind cranberry. First, identify the cranberry biomarkers. Know what’s in it, such as insoluble and soluble proanthocyanin (PAC) activity. Only then can you link that specific cranberry structure to outcome studies. Fruit d’Or is the first in the cranberry industry to accomplish this.

Researchers have linked the structure of specific soluble cranberry proanthocyanidins (PACs) found in Fruit d’Or’s Cran Naturelle whole fruit cranberry powder with a mechanism of action and efficacy. An in vitro study, conducted using Fruit d’Or’s Cran Naturelle whole-fruit cranberry powder, demonstrates the value of using state-of-the-art C-PAC reference standards in research.

The study was conducted by a third-party research company. Researchers used scanning electron microscopy to capture images of extra-intestinal pathogenic Escherichia coli (ExPEC) agglutinated in the presence of PACs from Cran Naturelle. C-PAC reference material, developed by Complete Phytochemical Solutions, was used to authenticate and quantify Cran Naturelle’s soluble and insoluble PACs. Fruit d’Or is the first cranberry ingredient supplier to identify the PAC constituents in its whole-fruit cranberry powder using the C-PAC reference standard.

The industry-sponsored scanning electron microscopy images taken from this study are the only ones captured to date. Images help visualize the structure-activity mechanism by which cranberry PACs interact with ExPEC. The agglutination effect is primarily attributed to the interaction of adhesive organelles on the surface of the ExPEC with cranberry PACs. They represent a tight link between Cran Naturelle’s soluble PACs and the biologic outcome.

Fruit d’Or is the first whole-fruit cranberry ingredient supplier to follow the protocol of first identifying the cranberry, knowing what’s in it, linking the PAC to standardization and then conducting the study to establish efficacy.

The C-PAC reference standard and associated analytic methods are “Fit for Purpose”. This term means that the methods and reference standards have been scientifically validated and represents the most appropriate approach to authenticate and quantify the bioactive PAC of whole-fruit cranberry. Without C-PAC, there is no accurate standardization. Lack of standardization leads to more fairy-dust cranberry products at the retail level. Moving forward to conduct a cranberry study, or repeating a study, is nearly impossible to do if what is in the starting cranberry powder or the reference standard used is unknown.

Fruit d’Or’s efforts to characterize its products’ unique characteristics enable them to demonstrate this structure/function claim on the pathogenic bacteria. Other cranberry products may have different activities. It’s incumbent on ingredient manufacturers to test their own unique products in order to make similar claims.

Cranberry ingredients and formulated products will vary from lot to lot because they are affected by every phase of the growing and manufacturing process, including drying and milling. That’s why it is so important to use ‘Fit for Purpose’ methods to authenticate and standardize the bioactive components’ starting material, then link that to its bioefficacy and standardization.



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